Pu’er tea is a fermented tea made by a special process in Yunnan Province. In recent years, it has been favored for its weight-loss and fat-reducing effect, but its mechanism has not been clarified.
Jia Wei’s research team started research on Pu’er tea 10 years ago. Researchers have systematically studied the dynamic changes of the chemical composition of Pu’er tea in the human body after drinking it, as well as the effect on the human metabolic network. It is found that the most prominent change after Pu’er tea enters the human body is that it can cause a series of changes in metabolites related to intestinal bacteria metabolism. This suggests that drinking Pu’er tea is likely to change and adjust the structure of intestinal bacteria.
Pu’er tea “shave oil”? It turned out that the intestinal bacterial structure was adjusted
On this basis, researchers have given normal and high-fat diet mice to drinking Pu’er tea for 26 weeks and found that after drinking Pu’er tea, the mice’s weight was significantly lower than that of the control group without changing or even increasing their diet. Total triglycerides and total cholesterol levels in the liver were significantly reduced. Volunteers drinking Pu’er tea after 4 weeks also showed a significant reduction in serum triglycerides and total cholesterol levels.
Researchers sequenced the gut bacteria of tea-drinking mice and volunteers and found that the structure and diversity of bacterial community containing bile salt hydrolase (BSH) in the intestine and feces were significantly reduced. Researchers have studied the correlation between the chemical components in tea and intestinal bacteria, and found that there is a high correlation between the tea brown pigment, a polyphenol polymer in Pu’er tea, and BSH bacteria. Drinking the tea brown pigment to mice, it was found that after 8 weeks, it showed the same or more obvious effect than that of Pu’er tea, which proved that the tea brown pigment is an effective chemical ingredient for weight loss and lipid reduction in Pu’er tea.
In order to find out the above molecular mechanism of action, the researchers transplanted the intestinal bacteria of mice with high-fat diet and high-fat diet drinking theophylline respectively to sterile mice. The results showed that the weight and blood lipid index of mice transplanted with theophylline intestinal bacteria were significantly lower than those of the control group. This study showed that the therapeutic effect of theophylline was achieved by specifically promoting alternative synthesis of bile acids in the liver.